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. 2015 Jul 16;7(1):72. doi: 10.1186/s13073-015-0196-5

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© Abraham et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — External validation results on the DQ2.5+ individuals in the North American dataset. a ROC curves for case/control prediction and b non-CD implicated per CD correctly implicated, ((1 – PPV)/PPV, equivalent to 1/(post-test-odds of disease)) versus sensitivity, for models developed on the European data and tested on the DQ2.5+ subset of the North American cohort. The DQ2.5 zygosity is the number of DQ2.5 alleles for each individual (heterozygous = 1, homozygous = 2). We assumed a CD prevalence of 10 % in the DQ2.5+, corresponding to a baseline implication ratio of 9:1, that is, all DQ2.5+ implicated as having CD at 100 % sensitivity