Table 1.

Classification of thrombotic microangiopathies (TMAs) (8)

Thrombotic Thrombocytopenic Purpura (TTP) Congenital ADAMTS 13 deficiency Anti-ADAMTS 13 antibodies

HELLP syndrome

HUS STEC-HUS Streptococcus pneumoniae-related HUS H1N1 and Influenza-related HUS Cobalamin C defect-HUS DGKE mutation-related HUS Complement-related HUS Complement gene mutations Complement factor H antibody HUS with coexisting disease / condition Infections (HIV) Solid organ and hematopoetic stem cell transplantation Malignancy / cancer chemotherapy Autoimmune disorders (SLE; APS; scleroderma) Drugs (CNI, sirolimus) malignant hypertension Unexplained HUS

APS: antiphospholipid syndrome; CNI: calcineurin inhibitors; DGKE: diacyl glycerol kinase epsilon; HIV: human immunodeficiency virus; HUS: hemolytic uremic syndrome; STEC: shiga-toxin producing E. coli; SLE: systemic lupus erythematosus