Table 2.

Clinical and laboratory properties of the diseases causing to complement-related HUS (6, 8, 43)

Subgroup	Frequency (%)	Age of onset	C3	ESRD(%)	Recureence (%)	Recurrence after transplantation
CFH	20–30	<2 years	N / ↓	50–70	50	75–90%
CFI	4–10	< 2 years	N / ↓	50–60	10–30	45–80%
MCP	5–15	>1 years	N / ↓	<20	70–90	<20%
C3	2–10	Any age	↓	60–80	50	40–70%
CFB	1–4	1 month	↓	50–70	Yes	100%
THBD	3–5	6 month	N / ↓	50–60	30	1 patient
Anti-CFH	6	5–13 years	N / ↓	30–40	10–60	Yes

C3: complement 3; CFB: complement factor B; CFH: complement factor H; CFI: complement factor I; HUS: hemolytic uremic syndrome; MCP: membrane cofactor protein; ESRD: end stage renal disease; THBD: thrombomodulin