TABLE 1.
Association of viruses with human cancer
| Cancer | No. of samples | No. of patientsa |
Other virusesb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HBV | HCV | EBV | CMV | HHV-6B | HPV16 | HPV38 | |||
| ACC (adrenocortical carcinoma) | 79 | ||||||||
| BLCA (bladder urothelial carcinoma) | 119 | 1 | 3 | 1 | 1 | 3 (HPV6) | |||
| BRCA (breast invasive carcinoma) | 125 | 1 | |||||||
| CESC (cervical squamous cell carcinoma) | 91 | 1 | 1 | 59 | 11 (HPV18), 9 (HPV45), 3 (HPV59), 13 (HPVother) | ||||
| COAD (colon adenocarcinoma) | 44 | 2 | 4 | 2 | 2 (HPyV6) | ||||
| DLBC (diffuse large B-cell lymphoma) | 28 | ||||||||
| GBM (glioblastoma multiforme) | 95 | ||||||||
| HNSC (head and neck squamous cell carcinoma) | 123 | 2 | 1 | 14 | 2 (HPV33), 2 (HPV35), 1 (HPV56), 1 (HHV-1) | ||||
| KICH (kidney chromophobe) | 66 | ||||||||
| KIRC (kidney renal clear cell carcinoma) | 67 | 1 (HPV18), 1 (HPV94) | |||||||
| KIRP (kidney renal papillary cell carcinoma) | 120 | ||||||||
| LGG (brain lower grade glioma) | 100 | 1 | |||||||
| LIHC (liver hepatocellular carcinoma) | 115 | 22 | 6 | 1 | 1 | 1 (HPV18), 1 (AAV2) | |||
| LUAD (lung adenocarcinoma) | 125 | ||||||||
| LUSC (lung squamous cell carcinoma) | 125 | 3 | 1 | 1 (HPV30) | |||||
| PRAD (prostate adenocarcinoma) | 124 | 1 | 1 | ||||||
| READ (rectum adenocarcinoma) | 36 | 5 | 4 | ||||||
| SKCM (skin cutaneous melanoma) | 82 | 1 | 1 | ||||||
| THCA (thyroid carcinoma) | 123 | ||||||||
| UCEC (uterine corpus endometrioid carcinoma) | 168 | 30c | |||||||
| UCS (uterine carcinosarcoma) | 57 | 1 | 1 (HPV5), 1 (HPV38b), 1 (HPV133) | ||||||
| Total | 2,012 | 23 | 6 | 14 | 17 | 5 | 77 | 30 | 55 |
a
The number of patients with each cancer type with observed viral sequences in the RNA-Seq data. HHV, human herpesvirus; HPV, human papillomavirus; HCV, hepatitis C virus; HBV, hepatitis B virus; CMV, cytomegalovirus. The numbers after the virus abbreviations represent subtypes.
b
The number of other viruses that were found in each cancer type, with the virus name in parentheses. AAV, adeno-associated virus; HPyV, human polyomavirus.
c
See Discussion in the text.