FIG 6.

Mapping of amino acid sequence conservation on ICP27-CTD structure. Based on multiple sequence alignment of ICP27 and its homologs, the conserved amino acid residues are mapped on the ICP27-CTD structure. Depending on the extent of conservation, the residues are colored from red, for highest conservation, to blue, for nonconserved residues. The upper inset shows the hydrophobic pocket, lined with conserved residues, along with the C-tail inserted in it. The lower inset displays the highly conserved zinc-binding residues. UCSF Chimera was used for rendering by sequence conservation. The final images were prepared in PyMOL.