FIG 4.
Crystal structures of N60-i3 Fab-gp12093TH057 coree-M48U1 and JR4 Fab-gp12093TH057 coree-M48 complex. Complexes are shown in ribbon representation (right panels), or the molecular surface is displayed over Fab molecules (left panels), with the light/heavy chain of N60-i3 Fab and JR4 Fab shown in light green/dark green and light cyan/dark cyan, respectively. The complementarity-determining regions (CDRs) are shown in slate (CDR L1), black (CDR L2), gray (CDR L3), green (CDR H1), orange (CDR H2), and pink (CDR H3). The gp120 outer domain is shown in raspberry, and the inner domain is shown in wheat (left panels) or colored in a layered color scheme (right panels), with the seven-stranded β-sandwich in magenta, layer 1 in yellow, layer 2 in cyan, and layer 3 in light wheat. The mimetic peptides M48U1 and M48 are shown in violet.