FIG 6.

Rendering of PET-CT images of ferret lungs at different time points after infection with the H1N1pdm virus. Stacked whole-lung images give 3-dimensional views at three time points following infection with 10⁶ TCID₅₀s of the H1N1pdm virus (A/KY/180/2010). Lungs from only one ferret per time point (including a mock-infected ferret at 3 dpi) are shown. Ferrets were injected with an intraperitoneal dose of radiolabeled FDG, and lungs were imaged using PET-CT 1 h later. For each image, the light pink surface corresponds to the border of the lung that was segmented from CT images by an automated CT analysis. PET-CT fusion images were used to define the uptake of FDG within the segmented lung space, and the intensity of FDG uptake is represented by small colored volumes within the lung borders. Regions of FDG uptake are colored according to voxel intensity within the FDG-PET image, as shown on the color scale on the right (from <0.05 [blue] to >0.5 [dark red]).