TABLE 1.
Top functional pathways altered by SLFN5 knockdown
| Pathway no. | Top diseases and functions | Molecules in network |
|---|---|---|
| 1 | Cell morphology, cellular assembly and organization, cellular function and maintenance | ACTBL2, ALKBH8, ATG16L2, ATR, BBS10, CCDC9, CCT2, CCT8, CEP164, CNN3, DAW1, DNAJC12, DNAJC27, DR1, DYRK2, FBXO25, HSPA9, ING3, KRT2, LRRFIP2, MAGOH, MPP3, MYO18A, NCL, NDRG1, NOLC1, PAN2, RPS2, SERBP1, SMN1/SMN2, TPM4, TTC8 |
| 2 | Cell morphology, infectious disease, hereditary disorder | ALOX5AP, ANKRD1, ANO3, ARHGAP28, ARRDC3, AZI1, BMPER, CBR3, CLEC11A, DMD, EPCAM, FBXO32, IL12A, KDM2A, MIB1, MYPN, NEBL, PAK1IP1, PNMA1, SENP2, SERPINB7, SNTB1, SNTB2, TNFRSF19, TNIP3, TNNT1, UHMK1, UNC5CL, VOPP1, WWP2, ZNF385A |
| 3 | Dermatological diseases and conditions, tissue morphology, cancer | ARHGAP21, C1orf106, CALB2, CCNA1, CDC42BPG, CREB3L1, CREB3L4, CTNNBIP1, ECM1, GANAB, GOLGA2, GORASP2, HABP2, HOXD3, JUP, KLHDC9, LTBP1, P24, PACS2, PCDHB14, PERP, QPCT, SCEL, SERPINA1, SERPINE1, SFN, SMARCE1, TGFA, TMEFF1, WDYHV1 |
| 4 | Developmental disorder, hematological disease, hereditary disorder | ACAP1, ADAMTSL4, C17orf103, CARD11, CATSPER1, CFI, CNTN1, CUBN, DDIT4, FKHR, GDF15, GNE, NTN4, PBXIP1, PID1, PPP2R1B, PRODH, PSAT1, PTPRB, RRP1B, SEMA6A, SH2B1, SIKE1, SORBS2, SPRR3, SULF2, SYNM, TINAG, TRIB3, UCN2 |
| 5 | Carbohydrate metabolism, cardiovascular disease, cellular development | ADAMTS1, ATP9A, BRIX1, CDK14, CDK16, Cg, CGB7, CREBL2, DDX21, DHRS3, ECE1, FRAT1, FRAT2, FSH, GATA6, GPIIB-IIIA, GRN, GSTZ1, HEXIM1, LYAR, MAF, MARCH3, NES, PHLDA1, POLR3G, RGS5, SACS, SLC16A6, STEAP1, TNPO1, UAP1 |
| 6 | Cellular assembly and organization, behavior, nervous system development and function | ANP32E, BCAS3, BRINP1, CLOCK, ING4, KIAA0020, MTUS1, NIP7, NPIPA1 (includes others), NR1D1, OPHN1, ORAI3, PAGR1, PATZ1, PER1, PNO1, PPARA, PPARGC1B, RFX3, SLFN5, SOX2, STK33, ZDHHC11, ZKSCAN1, ZNF76, ZNF33A |
| 7 | Connective tissue disorders, dermatological diseases and conditions, hereditary disorder | ANK2, COL12A1, COL17A1, COL4A1, COL6A1, COL6A2, COL6A3, COL6A5, CTGF, DOCK4, F11R, FBN1, FUT4, IL17RD, MMP13, PCOLCE2, RAB26, RABL6, RRBP1, RYR3, SEC23A, TGFB2, THBS1, TRPM2 |
| 8 | Cellular assembly and organization, nervous system development and function, cellular function and maintenance | AMPH, ATP8A2, DENR, DNM3, DUSP7, FXYD2, GBA, HTRA1, NGEF, PODXL, PP1/PP2A, PPP1CB, PPP1R14B, PPP1R16A, PPP1R9B, RABGEF1, SH2D4A, SIK1, SNAP25, SPTBN2, STX3, STX11, STX12, TNC, UNC13B |
| 9 | Lipid metabolism, molecular transport, small-molecule biochemistry | ABCC3, ACTR1B, AFP, CD163L1, CENPF, CORO2B, CP, CXADR, GLS, HPGD, interleukin-6 (IL-6), LONP1, MBL2, MIA2, MOK, MYO1D, PPL, RRP15, SPINT1, TBC1D9, TSC22D1, VEPH1, ZW10 |
| 10 | Hematological disease, metabolic disease, lipid metabolism | AKR1C3, ANGPTL4, B4GALT1, CCNG2, CYP27B1, ERLIN1, ERLIN2, ESRRG, FASN, FOXO4, GADD45A, GADD45B, GBP2, NFE2L1, NFKBIB, NR1H4, PNRC1, POLR3F, PPARGC1A, RNF139, RXRB, T3-TR-RXR, TK2, TSPAN1, ZNRD1 |