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. 2015 Jul 2;35(15):2641–2657. doi: 10.1128/MCB.00380-15

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FIG 3 — Differential expression of heart biomarkers and lipid genes in male and female Pcyt2^+/− hearts. (A and B) Representative expression of heart failure genes and genes involved in the heart fatty acid transport and metabolism in 8-month-old male and female hearts. Each lane (n = 3) represents separate Pcyt2^+/− and Pcyt2^+/+ animals. (C to E) Quantification (n = 6 for each group) reveals significant upregulation of the fatty acid transporter gene Cd36 (C) and the lipoprotein lipase gene Lpl (D) and significant downregulation of Nppa (E) in Pcyt2^+/− male hearts. (F to H) Conversely, there is significant downregulation of Cd36 (G) and α-actin (Acta) (F) and upregulation of Myh7 (H) in Pcyt2^+/− female hearts. The surface G-protein (estrogen) receptor Gpr30 is detected only in Pcyt2^+/− and Pcyt2^+/+ female hearts. The values are means ± SEM. *, P < 0.05 by a two-tailed or one-tailed Student t test.