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. 2015 Jul 2;35(15):2641–2657. doi: 10.1128/MCB.00380-15

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FIG 4 — Gender-dependent expression of metabolic and hypertension genes in Pcyt2^+/− heart. (A) Genes identified as differently expressed in 8-month-old male and female hearts. (B) The monocarboxylate (lactate) transporter gene Mct1 is significantly upregulated in both Pcyt2^+/− male and female hearts; however, the Mct1 expression level is significantly higher in Pcyt2^+/− female hearts than in Pcyt2^+/− male hearts. (C) The angiotensin-converting enzyme 1 gene AceI is significantly upregulated in Pcyt2^+/− male heart versus littermate controls. Control female hearts have low AceI expression levels, and the expression level remained relatively low in Pcyt2^+/− female hearts in comparison to Pcyt2^+/− males. (D) The mitochondrial regulator Pgc1α is significantly upregulated in control female hearts relative to control male hearts. Pgc1α expression was also significantly upregulated in Pcyt2^+/− female hearts relative to Pcyt2^+/− male hearts. (E) Expression of the stearoyl-CoA desaturase gene Scd1 is significantly upregulated in Pcyt2^+/− female versus Pcyt2^+/− male hearts. Scd1 expression is significantly upregulated in Pcyt2^+/− female hearts versus littermate controls. Values are means ± SEM (n = 6 in each group). *, P < 0.05; **, P < 0.01; ***, P < 0.001 (by two-tailed Student t test).