FIG 1.

Acute severity and cumulative recurrences in the guinea pig ocular model. (A) Severity of acute infection from 1 to 14 dpi, graphed as the mean lesion score for each group of guinea pigs on each day of observation, based on a scale of 0 to 4 (0, no symptoms; 1, inflammation or redness; 2, 1 or 2 lesions; 3, 3 to 5 lesions; 4, >5 lesions or coalescence of lesions); HSV-1, n = 40; HSV-2, n = 42; P = 0.002 by Mann-Whitney test. (B) Cumulative recurrences per guinea pig for each group during latent infection from 15 to 60 dpi; HSV-1, n = 11; HSV-2, n = 9; P = 0.020 by Mann-Whitney test. (C) Representative images of HSV-1 and HSV-2 acute (day 7) and recurrent (HSV-1, day 22; HSV-2, day 39) ocular disease.