TABLE 2.
Description of reagents used to characterize the SIVsm Env panela
| Reagent | Target | Provider | Catalog no. | Source | Reference(s) |
|---|---|---|---|---|---|
| Rhesus anti-HIV-2 MAb 3.11H | V3 | James E. Robinson | SIV/17E-CL-infected RM at ∼12 mo | 17, 49 | |
| Human anti-HIV-2 MAb 6.10B | CD4bs | James E. Robinson | HIV-2-infected Gambian subject N37126 | 17, 49–53 | |
| Human anti-HIV-2 MAb 1.4H | CD4i | James E. Robinson | HIV-2-infected Gambian subject N37126 | 17, 49–53 | |
| Mouse anti-SIVmac251 MAb | gp120 | Advanced Bioscience Laboratories, Inc. | 4327 | ||
| AMD-3100 (JM-2987) | CXCR4 | AIDS Reagent Program | 8128 | 54–56 | |
| Maraviroc (Selzentry) | CCR5 | AIDS Reagent Program | 11580 | 57, 58 | |
| Recombinant human sCD4 | CD4bs | AIDS Reagent Program/Progenics | 4615 | ||
| T1249 | gp41 HR1 | Trimeris | 59 | ||
| SIVmac239-infected RM plasma pool | Polyclonal | Francois Villinger, Yerkes | 20 rhesus macaques ∼33 wk after SIV infection | ||
| SIVmac251-infected RM plasma pool 1 | Polyclonal | Rama R. Amara, Yerkes | 15 RMs ∼16 wk after SIV infection | ||
| SIV-infected SM pool | Polyclonal | Francois Villinger, Yerkes | 29 naturally SIV-infected SMs | ||
| SIVmac251-infected serum pool 2 | Polyclonal | AIDS Reagent Program | 2773 | 6 SIV-infected RMs | 60 |
| Normal RM serum pool | NA | Yerkes | 8 uninfected, unvaccinated RMs |
a
SM, sooty mangabey; RM, rhesus macaque; NA, not available.