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. 2015 Jun 3;89(16):8428–8443. doi: 10.1128/JVI.00997-15

FIG 4.

FIG 4

Effects of compounds 1 to 3 on the entry pathway of different arenaviruses. 293A cells were transduced with retroviral or lentiviral vectors pseudotyped with GPs from the indicated viruses. Transductions were performed in the presence of DMSO alone or the indicated concentrations of compound 1, 2, or 3. Relative titers are shown as percentages of the control titer (DMSO treated). (A) NW clade B GP vectors. (B) NW clade A/B GP vectors. (C) NW clade A GP vectors. (D) NW clade C GP vectors. (E) OW GP vectors. Mean titers (in TU per milliliter) on DMSO-treated cells were as follows: 2.0 × 105 for JUNV, 3.4 × 104 for MACV, 9.3 × 104 for TCRV, 4.6 × 104 for GTOV, 4.6 × 104 for AMAV, 8.1 × 103 for WWAV, 8.2 × 103 for BBTV, 8.8 × 103 for SKTV, 6.7 × 103 for FLEV, 2.8 × 105 for PICV, 1.3 × 105 for OLVV, 6.3 × 103 for LATV, 9.0 × 105 for LASV, 2.8 × 105 for LCMV13, and 3.3 × 105 for LCMV53b. All data represent the means ± standard deviations from 3 to 7 independent experiments. All data from panels A, B, and D were statistically significant compared to the DMSO control (P < 0.001), and in panels C and E, statistical significance compared to the DMSO control is indicated (*, P < 0.05; ***, P < 0.001).