FIG 5.

Effects of compounds 1 to 3 on the entry pathway of other viruses. 293A or NIH 3T3 cells (for ecotropic MLV GP vectors) were transduced with retroviral or lentiviral vectors pseudotyped with the indicated viral attachment/fusion proteins. Transductions were performed in the presence of DMSO alone or the indicated concentrations of compound 1, 2, or 3. Relative titers are shown as percentages of the control titer (DMSO treated). Mean titers (in TU per milliliter) on DMSO-treated cells were as follows: 3.0 × 10⁶ for VSV, 4.8 × 10⁴ for amphotropic MLV, 8.2 × 10⁴ for ecotropic MLV, 9.0 × 10⁴ for Ebola virus, 2.5 × 10³ for influenza virus H7, 5.2 × 10⁴ for Hendra virus, and 4.2 × 10⁵ for Nipah virus. All data represent the means ± standard deviations from 3 to 7 independent experiments. Statistical significance compared to the DMSO control is indicated (****, P < 0.0001).