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Use of the estimated error rate and the Poisson distribution of errors to make cutoffs for low-abundance mutations in the HIV-1 protease regiona
| No. of mutations per position | No. of positions from the Poisson distribution (errors) | No. of positions observed |
|---|---|---|
| 1 | 79 | 68 |
| 2 | 12 | 35 |
| 3 | 1 | 20 |
| 4 | 0 | 13 |
| ≥5 | 0 | 92 |
From a protease inhibitor treatment-naive patient sample. The number of consensus sequences was 3,178. The estimated substitution rate was 0.01%. The length of the sequences was 340 bp.
