Table 2.
Hemodynamic and Indices of Autonomic Function Before and After Ivabradine.
| Parameter | Baseline | Ivabradine | ||
|---|---|---|---|---|
| Rest | Tilt | Rest | Tilt | |
| HR (bpm) | 70±3 | 118±4 | 66±2* | 101±5* |
| Systolic BP (mmHg) | 113±5 | 114±4 | 114±3 | 115±4 |
| Diastolic BP (mmHg) | 68±3 | 75±3 | 67±3 | 74±4 |
| Valsalva ratio | 1.43±0.1 | - | 1.52±0.2 | - |
| RMSSD | 35±4 | 16±2 | 28±6 | 18±2 |
| Lfrri | 715±160 | 470±180 | 790±150 | 390±120 |
| Hfrri | 790±120 | 180±80 | 840±140 | 210±90 |
| Lfrri/Hfrri ratio | 1.15±0.2 | 3.9±1.0 | 0.95±0.1 | 4.1±1.2 |
| LfBP | 1.5±0.6 | 5.1±1.2 | 1.6±0.5 | 4.7±1.0 |
*
Significant differences between the baseline and the tilt.
BP, blood pressure; bpm, beats per minute; Hfrri, RR intervals high-frequency domain; HR, heart rate; LfBP, BP low-frequency domain; Lfrri, RR intervals low-frequency domain; RMSSD, root mean square of the successive differences.