Table 1.

The efficiency of inversions, duplications, and deletions by CRISPR with a pair of sgRNAs.

DNA fragment	β-globin RE1	Pcdh RE1	β-globin RE2	HoxD locus	β-globin locus	Pcdhα cluster	Pcdh α, β, and γ clusters
(size in bp)	(709)	(1272)	(6277)	(18142)	(80732)	(256744)	(807480)
Inversion (%)	21.12 ± 4.99	23.28 ± 2.42	23.13 ± 1.13	7.28 ± 1.60	5.96 ± 0.28	5.48 ± 0.37	0.71 ± 0.12
Duplication (%)	ND	0.23 ± 0.12	5.30 ± 1.19	ND	5.97 ± 0.33	0.61 ± 0.02	0.17 ± 0.03
Deletion (%)	28.33 ± 6.19	17.51 ± 1.04	34.49 ± 3.57	9.15 ± 0.11	13.39 ± 0.80	8.46 ± 0.24	0.47 ± 0.08

ND, not detectable. Efficiency = mean ± SD.