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. 2015 Jul 28;10:4731–4746. doi: 10.2147/IJN.S83150

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© 2015 Uchiyama et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Typical series of MRI images of a Wistar rat treated with 50 mg/kg of cat-USPIOs as a function of time from zero up to 140 days after IV administration, highlighting the contrast in liver and spleen.

Notes: The negative contrast in the left thigh is due to the accumulation of cat-USPIOs induced by a magnet placed on that local for 2 hours after IV injection. The liver and the spleen are indicated by a yellow rectangle; and a blue circle indicates the negative contrast in the thigh.

Abbreviations: cat-USPIOs, cationic ultrasmall superparamagnetic iron oxide nanoparticles; MRI, magnetic resonance imaging; IV, intravenous.