Figure 8.

Effect of cat-USPIOs on leukocyte-endothelial interactions evaluated in male Wistar rat liver sinusoids by intravital microscopy.

Notes: (A) Fluorescence intravital microscopy images showing the number of rhodamine 6G-labeled leukocytes adhered to the liver sinusoids 3 hours after intravenous injection (1 mL, single dose) of saline (control, above) and 10 mg/kg cat-USPIOs suspension (experimental, below). (B) Average number of adhered leukocytes in 100 µm segments of sinusoid walls considering at least five sinusoids per rat. White arrows indicate adhered leukocytes. Bar =100 µm.

Abbreviation: cat-USPIOs, cationic ultrasmall superparamagnetic iron oxide nanoparticles.