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The mean plasma concentrations of carvedilol (A) and AUC (B) after oral administration of niosomes to Wistar rats pretreated with cycloheximide (n=6, mean ± SEM) (*P<0.05 vs control).
Notes: SC20%: 20% SC-enriched niosomes; DCP10%: anionic niosomes containing 10% DCP.
Abbreviations: AUC, area under the drug concentration–time curve; F, formulation; DCP, dicetyl phosphate; SC, sodium cholate; SEM, standard error of the mean.
