Table 2.
The composition, %EE, zeta potential and particle size of bile salt-enriched niosomal formulations
| Formulation | Niosome composition (molar ratio)
|
Symbol | %EE | Zeta potential (mV) | Z-average (nm) | PDI | |||
|---|---|---|---|---|---|---|---|---|---|
| Span 60 | Chol | Bile salts
|
|||||||
| SC | STC | ||||||||
| F1 (plain niosome) | 80 | 20 | – | – | PN | 84.8±2.7 | −27.7±3.4 | 417.4±19.1 | 0.31±0.02 |
| F2 | 64 | 16 | 20 | – | SC20% | 89.4±3.9 | −54.7±6.9 | 347.9±10.7 | 0.35±0.05 |
| F3 | 56 | 14 | 30 | – | SC30% | 86.2±2.9 | −58.5±4.8 | 441.0±18.1 | 0.37±0.04 |
| F4 | 64 | 16 | – | 20 | STC20% | 96.7±1.2 | −59.9±3.6 | 476.9±14.4 | 0.31 ±0.03 |
| F5 | 56 | 14 | – | 30 | STC30% | 96.0±2.2 | −69.9±2.8 | 384.4±12.5 | 0.34±0.03 |
Note: Data represent the mean ± SEM.
Abbreviations: Chol, cholesterol; EE, entrapment efficiency; PDI, polydispersity index; SC, sodium cholate; SEM, standard error of the mean; STC, sodium taurocholate.