Table 3.
The composition, %EE, zeta potential and particle size of niosomal formulations after addition of different charge inducing agents
| Formulation | Niosome composition (molar ratio)
|
Symbol | %EE | Zeta potential (mV) | Z-average (nm) | PDI | |||
|---|---|---|---|---|---|---|---|---|---|
| Span 60 | Chol | Charge-inducing agents
|
|||||||
| CTAB | DCP | ||||||||
| F6 | 76 | 19 | 5 | – | VNFa | – | – | – | |
| F7 | 72 | 18 | 10 | – | CTAB10% | 80.1±2.9 | +56.0±5.0 | 496.6±20.6 | 0.42±0.01 |
| F8 | 68 | 17 | 15 | – | 92.7±3.8 | +72.1±3.3 | 165.5±1.7 | 0.18±0.02 | |
| F9 | 76 | 19 | – | 5 | 54.1±2.8 | −52.4±2.8 | 457.9±0.6 | 0.43±0.05 | |
| F10 | 72 | 18 | – | 10 | DCP10% | 90.1±1.4 | −83.5±3.9 | 379.6±11.4 | 0.34±0.04 |
Note: Data is presented as n=3, mean ± SEM.
a
Vesicles were not formed.
Abbreviations: Chol, cholesterol; CTAB, hexadecyl-trimethyl ammonium bromide; DCP, dicetyl phosphate; EE, entrapment efficiency; PDI, polydispersity index; SEM, standard error of the mean.