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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Neuroscience. 2015 Mar 19;295:23–38. doi: 10.1016/j.neuroscience.2015.03.015

Fig. 4.

Fig. 4

Exercise induces hypoxia in SNpc DA neurons. (A, B) C57BL/6 mice in the SH condition taken during the evening active period show DA neurons labeled with TH (A) but not Elk3-51 (B). (C, D) SNpc from C57BL/6 mice in wheel cages taken during day 2 in the active period (running) show DA neurons colabeled with TH (C) and Elk3-51 (D). (E) All of the mice in exercise conditions injected with EF-5 (5/5) show Elk3-51 labeling of DA neurons, while none of the mice in SH injected with EF-5 (0/5) show Elk3-51+ DA neurons.