TABLE 3.
Factors affecting overall survival and disease-specific survival.
| OS |
DSS |
|||||||
|---|---|---|---|---|---|---|---|---|
| Univariate model |
Multivariate model |
Univariate model |
Multivariate model |
|||||
| Factors | HR (95% CI) |
p
value |
HR (95% CI) |
p
value |
HR (95% CI) |
p
value |
HR (95% CI) |
p
value |
| Age at diagnosis, y* | ||||||||
| ≤50 (n = 33) | 1 | 1 | 1 | 1 | ||||
| 51–60 (n = 45) | 3.29 (1.31–8.26) | .001 | 2.82 (0.99–8.11) | .002 | 2.66 (1.04–6.82) | .01 | 1.97 (0.66–5.90) | .01 |
| 61–70 (n = 65) | 4.89 (2.03–11.81) | 4.05 (1.48–11.04) | 3.94 (1.61–9.64) | 3.10 (1.09–8.78) | ||||
| >70 (n = 85) | 4.69 (1.99–11.10) | 3.97 (1.50–10.51) | 2.38 (0.97–5.82) | 2.00 (0.71–5.61) | ||||
| Sex† | ||||||||
| Male (n = 166) | 1 | 1 | 1 | 1 | ||||
| Female (n = 62) | 1.03 (0.65–1.62) | .90 | 1.13 (0.68–1.88) | .64 | 1.08 (0.64–1.83) | .77 | 1.21 (0.67–2.19) | .53 |
| Primary site‡ | ||||||||
| Parotid (n = 163) | 1 | 1 | 1 | 1 | ||||
| Submandibular (n = 33) |
1.28 (0.76–2.15) | .35 | 1.34 (0.76–2.37) | .32 | 1.48 (0.83–2.65) | .18 | 1.57 (0.83–2.98) | .17 |
| Tumor grade§ | ||||||||
| Well or moderately differentiated (n = 29) |
1 | 1 | 1 | 1 | ||||
| Poorly or undifferentiated (n = 120) |
2.36 (1.16–4.82) | .02 | 2.10 (1.02–4.34) | .05 | 2.63 (1.11–6.23) | .02 | 2.50 (1.03–6.07) | .04 |
| Overall stage§ | ||||||||
| I or II (n = 78) | 1 | 1 | 1 | 1 | ||||
| III (n = 49) | 2.17 (1.18–3.98) | 1.76 (0.95–3.27) | 1.62 (0.75–3.51) | 1.35 (0.62–2.98) | ||||
| IV-A or IV-B (n = 85) | 3.52 (2.03–6.10) | < .001 | 3.47 (1.99–6.08) | < .001 | 3.60 (1.89–6.86) | < .001 | 3.53 (1.84–6.79) | < .001 |
| IV-C (n = 13) | 9.37 (4.40–19.97) | 9.46 (4.40–20.37) | 11.86 (5.28–26.62) | 12.23 (5.37–27.89) | ||||
| Lymph node status§ | ||||||||
| Negative (n = 114) | 1 | 1 | 1 | 1 | ||||
| Positive (n = 111) | 2.58 (1.68–3.94) | < .001 | 2.44 (1.59–3.76) | < .001 | 3.21 (1.92–5.38) | < .001 | 3.98 (1.86–5.28) | < .001 |
| Tumor size§ | ||||||||
| ≤2 cm (n = 85) | 1 | 1 | 1 | 1 | ||||
| >2–3 cm (n = 50) | 1.05 (0.59–1.86) | .03 | 1.01 (0.56–1.80) | .05 | 0.69 (0.32–1.47) | .03 | 0.66 (0.31–1.42) | .03 |
| >3 cm (n = 58) | 1.90 (1.15–3.13) | 2.01 (1.19–3.40) | 2.00 (1.14–3.51) | 1.99 (1.10–3.58) | ||||
| Treatment type†† | ||||||||
| Surgery only (n = 60) | 1 | 1 | 1 | 1 | ||||
| Adjuvant radiation (n = 161) |
1.65 (1.02–2.68) | .04 | 0.99 (0.57–1.73) | .39 | 1.84 (1.01–3.33) | .05 | 1.08 (0.54–2.15) | .28 |
| Year of diagnosisf | ||||||||
| 1973–2000 (n = 86) | 1 | 1 | 1 | 1 | ||||
| 2000–2008 (n = 142) | 1.56 (0.98–2.47) | .07 | 1.03 (0.62–1.71) | .91 | 1.97 (1.04–3.38) | .03 | 1.23 (0.67–2.23) | .51 |
Abbreviations: OS, overall survival; DSS, disease-specific survival, HR, hazard ratio; CI, confidence interval.
Multivariate models adjusted for sex, race, tumor site, size, lymph node status, and treatment modality.
Multivariate models adjusted for age, race, tumor site, size, lymph node status, and treatment modality.
Multivariate models adjusted for age, sex, race, tumor size, lymph node status, and treatment modality.
Multivariate models adjusted for age, sex, race, tumor site, and treatment modality.
Multivariate models adjusted for age, sex, race, tumor site, size, and lymph node status.
Multivariate models adjusted for age, sex, race, tumor site, size, lymph node status, and treatment modality.