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. 2015 Jul 30;21:2210–2217. doi: 10.12659/MSM.893859

Figure 1.

Figure 1

MiR-375 expression is negatively related to radioresistance in HR-HPV (+) cervical cancer. (A, C) qRT-PCR analysis of relative miR-375 expression in serum (A) and tissue (C) of cervical cancer patients (n=22) and healthy controls (n=20). Relative miR-375 expression was significantly higher in serum (A) and tissue (C) of HR-HPV (+) cervical cancer patients than in healthy controls. (B, D) qRT-PCR analysis showed that miR-375 expression was even lower in both serum (B) and tissue (D) of radioresistant patients (n=13) than in radiosensitive patients (n=9). (E) The surviving fraction of HPV-18-positive HeLa cells was significantly lower than in HPV-16-positive SiHa cells under radiation treatment. (F) qRT-PCR analysis showed that miR-375 expression was significantly lower in SiHa cells than in HeLa cells. Each bar represents the mean ±S.D. of 3 experiments. * P<0.05; ** P<0.01, *** P<0.001.