Table 6. DRG Gene Expression Comparing Sham and CCI: Effects of Age.
Gene | Fold MS/YS | p value | Gene | Fold MCCI/YCCI | p value |
---|---|---|---|---|---|
ATF3 | 2.71 | 0.8902 | ATF3 | 0.70 | 0.6927 |
CCL2 | 1.04 | 0.9842 | CCL2* | 1.16 | 0.0862 |
CD2 | 1.61 | 0.2815 | CD2 | 0.93 | 0.9693 |
CD3E | 1.38 | 0.7717 | CD3E | 1.72 | 0.4092 |
CD45* | 1.61 | 0.0691 | CD45 | 0.97 | 0.9982 |
CD68 | 1.57 | 0.1547 | CD68 | 0.72 | 0.0412 |
GFAP | 1.29 | 0.8798 | GFAP | 0.82 | 0.722 |
IFN-γ | 1.50 | 0.7557 | IFN-γ | 0.77 | 0.6489 |
IL10 | 0.43 | 0.5449 | IL10 | 0.75 | 0.9853 |
IL17a | 3.28 | 0.4017 | IL17a | 0.86 | 0.9526 |
IL1β | 1.22 | 0.7231 | IL1β | 0.71 | 0.0209 |
IL6 | 1.46 | 0.9945 | IL6 | 0.86 | 0.7814 |
TGFβ1* | 1.42 | 0.0605 | TGFβ1 | 0.95 | 0.9681 |
TNFα | 2.24 | 0.5179 | TNFα | 0.68 | 0.3829 |
Two-way ANOVA results (normalized as described in Table 1) of dorsal root ganglia are shown with contrasts and associated p values and numbers of animals assayed per group. Bolded/italicized genes indicate specific contrast differences p < 0.05
* indicates difference trending to significance.
Abbreviations are as in Table 2.