Table 1. Best candidates Salm/Salr Target Genes (STG OK).
Best Candidates Spalt-repressed genes | ||||||
Name | Symbol | Array | Ph | IS | Molecular | MC |
CG10916 | CG10916 | Df/UAS | S-P | U+ | Zinc ion binding | D |
CG10965 | Corp | 24/48 | S | N+ | Response to DNA damage | CD |
CG11086 | Gadd45 | 24/48 | + | N+ | JNK cascade | CS |
CG11897 | CG11897 | 24/48 | + | U+ | ABC transporter | Tra |
CG1303 | agt | Df/UAS | + | U+ | DNA methylation | D |
CG14121 | ver | Df/UAS | + | U+ | Telomere capping | D |
CG14907 | CG14907 | 24/48 | + | N+ | -------------- | CG |
CG15784 | CG15784 | 24/48 | S-P | S+ | -------------- | CG |
CG16928 | mre11 | Df/UAS | + | N+ | Nucelase activity | D |
CG17104 | CG17104 | 24/48 | + | SS+ | -------------- | CG |
CG17530 | GstE6 | 24/48 | + | N+ | Glutathione S-transferase | RedOx |
CG17533 | GstE8 | 24/48 | S | U+ | Glutathione transferase | RedOx |
CG18213 | CG18213 | Df/UAS | + | N+ | Zinc finger | CGh |
CG18455 | Optix | 24/48 | S-P | SS+ | Sequence-specific DNA binding | D |
CG18522 | CG18522 | 24/48 | + | N+ | Oxidoreductase | RedOx |
CG1925 | mus205 | Df | Bs//S | U+ | DNA binding | D |
CG2909 | CG2909 | 24/48 | V+ | U+ | -------------- | CG |
CG2999 | unc-13 | Df/UAS | + | S+ | Intracellular signal transduction | CS |
CG3008 | CG3008 | UAS | S-P | U+ | Protein kinase activity | P |
CG3074 | Swim | 24/48 | + | U+ | Wnt-protein binding | CS |
CG32021 | CG32021 | Df/UAS | V-/S | N+ | -------------- | CG |
CG32625 | CG32625 | 24/48 | + | U+ | CHHC zinc finger | CGh |
CG33048 | Mocs1 | 24/48 | -------- | U+ | Mo-molybdopterin cofactor | M |
CG3448 | CG3448 | 24/48 | + | N+ | DNA repair protein XRCC4 | D |
CG43144 | CG43144 | 24/48 | ------- | N+ | Non protein coding gene | CR |
CG45050 | CG43674 | 24 | + | U+ | DNA binding | D |
CG5096 | CG5096 | 24/48 | + | U+ | Leucine-rich repeat | CGh |
CG5202 | escl | UAS | + | U+ | Histone methyltransferase | D |
CG5247 | Irbp | UAS | S-P | U+ | DNA binding | D |
CG6272 | CG6272 | Df/UAS | EPL | N+ | Sequence-specific DNA bind | D |
CG6658 | Ugt86Di | 24/48 | + | SS+ | Glucuronosyltransferase | M |
CG7590 | scyl | 24/48 | + | U+ | Response to DNA damage | CD |
Best Candidates Spalt-activated genes with a Spalt-related phenotype | ||||||
Name | Symbol | Array | Ph | IS | Molecular | MC |
CG11357 | CG11357 | Df | Bs | U- | Transferring glycosyl groups | P |
CG11607 | H2.0 | UAS | sS-P | U- | DNA binding transcription factor | D |
CG11883 | CG11883 | UAS | S-P | U- | 5'-nucleotidase activity | D |
CG12182 | CG12182 | 24/48 | S-P | U- | -------------- | CG |
CG12287 | pdm2 | UAS | Bs | U- | DNA binding | D |
CG13083 | CG13083 | 24/48 | S-P | U- | -------------- | CG |
CG14394 | NijC | 24/48 | Bs/S/V+ | U- | Ninjurin | CA |
CG15739 | CG15739 | Df/UAS | S-P | U- | Phosphatase activity | P |
CG16705 | SPE | Df | S-P | U- | Serine-type endopeptidase | P |
CG16756 | CG16756 | Df | S | U- | Lysozyme activity | P |
CG1725 | dlg1 | Df | S-P | U- | EGFR binding | CS |
CG1869 | Cht7 | Df | S-P | SS- | Chitinase activity | Cut |
CG30069 | CG30069 | Df | S/Bs | SS- | -------------- | CG |
CG31098 | CG10634 | Df/UAS | V+ | U- | Transferase activity | P |
CG31436 | CG31436 | 24/48 | S/V- | U- | CHK kinase-like | CGh |
CG32029 | Cpr66D | Df/UAS | S/Bs | U- | Structural constituent of cuticle | Cut |
CG32055 | CG32055 | Df/UAS | S | SS- | Insulin-like growth factor bind | CS |
CG32261 | Gr64a | UAS | S | U- | Taste receptor activity | CS |
CG33197 | mbl | Df/UAS | Bs | U- | DNA binding | D |
CG33302 | Cpr31A | 24/48 | S/Bs | U- | Structural constituent of cuticle | Cut |
CG42614 | scrib | UAS | S-P | U- | Protein binding | CS |
CG4322 | moody | UAS | S-P | U- | Melatonin receptor activity | CS |
CG4379 | Pka-C1 | UAS | S-P | U- | Protein binding | CS |
CG4570 | CG4570 | 24/48 | S | U- | Transposase, Tc1-like | D |
CG5249 | Blimp-1 | UAS | S-P | U- | Nucleic acid binding | D |
CG7160 | Cpr78E | 24/48 | S | U- | Cuticle | Cut |
CG7577 | ppk20 | Df/UAS | S | U- | Sodium channel activity | Tra |
CG7734 | shn | UAS | S-P | U- | DNA binding transcription factor | D |
CG8084 | ana | UAS | S-P | SS- | Growth factor activity | CS |
CG8675 | CG8675 | Df | S-P | U- | -------------- | CG |
CG8768 | CG8768 | 24/48 | S | U- | NAD epimerase/dehydratase | M |
CG8780 | tey | UAS | S/Bs | U- | Regulation of transcription | D |
CG9333 | Oseg5 | 24/48 | S/V+ | U- | WD40-repeat | CGh |
CG9355 | dy | UAS | S-P | U- | Structural constituent of cuticle | Cut |
“Array” indicates the experiment which the genes were selected, experiment 1 (24/48) or experiment 2 (Df//UAS). “Ph” indicates the phenotype of nub-Gal4/UAS-RNA-i and sal EPv -Gal4/UAS-RNA-i separated by double dash: + (WT); S (wing size); P (vein pattern); S-P (wing size and vein pattern); V+ and V- (extra-veins and loss of veins); Bs (dorso-ventral wing surface adhesion); EPL (early pupal lethal). “IS” indicates the mRNA expression patterns in wild type and salm-i/salr-i discs (N: expression not detected; U: generalised expression and P: patterned expression). We indicated by “+” or “-”that the expression appears ectopic or is reduced in salmi/salri discs, respectively. “Molecular” indicates the molecular nature and simplified molecular class (MC), respectively: D (genes related with the biology of DNA), P (genes related with proteins metabolism), CG (genes without known functional domains or orthology), CS (genes encoding components of signalling pathways), CGh (genes with a known functional domain but not clear orthology relationships), M (genes encoding proteins related to the metabolism of lipids or glucids), CA (genes related with cell adhesion or the cytoskeleton), Cut (genes encoding proteins related with structural constituent of cuticle), Tra (genes related with the transport of metabolites across cellular membranes), RedOx (genes encoding proteins related with oxidation-reduction process), CD (genes related with cell death) and CR (non protein coding gene).