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. 2015 Aug 4;11(8):e1005370. doi: 10.1371/journal.pgen.1005370

Table 1. Best candidates Salm/Salr Target Genes (STG OK).

Best candidates Spalt-repressed genes and Best candidates Spalt-activated genes with a Spalt-related phenotype.

Best Candidates Spalt-repressed genes
Name Symbol Array Ph IS Molecular MC
CG10916 CG10916 Df/UAS S-P U+ Zinc ion binding D
CG10965 Corp 24/48 S N+ Response to DNA damage CD
CG11086 Gadd45 24/48 + N+ JNK cascade CS
CG11897 CG11897 24/48 + U+ ABC transporter Tra
CG1303 agt Df/UAS + U+ DNA methylation D
CG14121 ver Df/UAS + U+ Telomere capping D
CG14907 CG14907 24/48 + N+ -------------- CG
CG15784 CG15784 24/48 S-P S+ -------------- CG
CG16928 mre11 Df/UAS + N+ Nucelase activity D
CG17104 CG17104 24/48 + SS+ -------------- CG
CG17530 GstE6 24/48 + N+ Glutathione S-transferase RedOx
CG17533 GstE8 24/48 S U+ Glutathione transferase RedOx
CG18213 CG18213 Df/UAS + N+ Zinc finger CGh
CG18455 Optix 24/48 S-P SS+ Sequence-specific DNA binding D
CG18522 CG18522 24/48 + N+ Oxidoreductase RedOx
CG1925 mus205 Df Bs//S U+ DNA binding D
CG2909 CG2909 24/48 V+ U+ -------------- CG
CG2999 unc-13 Df/UAS + S+ Intracellular signal transduction CS
CG3008 CG3008 UAS S-P U+ Protein kinase activity P
CG3074 Swim 24/48 + U+ Wnt-protein binding CS
CG32021 CG32021 Df/UAS V-/S N+ -------------- CG
CG32625 CG32625 24/48 + U+ CHHC zinc finger CGh
CG33048 Mocs1 24/48 -------- U+ Mo-molybdopterin cofactor M
CG3448 CG3448 24/48 + N+ DNA repair protein XRCC4 D
CG43144 CG43144 24/48 ------- N+ Non protein coding gene CR
CG45050 CG43674 24 + U+ DNA binding D
CG5096 CG5096 24/48 + U+ Leucine-rich repeat CGh
CG5202 escl UAS + U+ Histone methyltransferase D
CG5247 Irbp UAS S-P U+ DNA binding D
CG6272 CG6272 Df/UAS EPL N+ Sequence-specific DNA bind D
CG6658 Ugt86Di 24/48 + SS+ Glucuronosyltransferase M
CG7590 scyl 24/48 + U+ Response to DNA damage CD
Best Candidates Spalt-activated genes with a Spalt-related phenotype
Name Symbol Array Ph IS Molecular MC
CG11357 CG11357 Df Bs U- Transferring glycosyl groups P
CG11607 H2.0 UAS sS-P U- DNA binding transcription factor D
CG11883 CG11883 UAS S-P U- 5'-nucleotidase activity D
CG12182 CG12182 24/48 S-P U- -------------- CG
CG12287 pdm2 UAS Bs U- DNA binding D
CG13083 CG13083 24/48 S-P U- -------------- CG
CG14394 NijC 24/48 Bs/S/V+ U- Ninjurin CA
CG15739 CG15739 Df/UAS S-P U- Phosphatase activity P
CG16705 SPE Df S-P U- Serine-type endopeptidase P
CG16756 CG16756 Df S U- Lysozyme activity P
CG1725 dlg1 Df S-P U- EGFR binding CS
CG1869 Cht7 Df S-P SS- Chitinase activity Cut
CG30069 CG30069 Df S/Bs SS- -------------- CG
CG31098 CG10634 Df/UAS V+ U- Transferase activity P
CG31436 CG31436 24/48 S/V- U- CHK kinase-like CGh
CG32029 Cpr66D Df/UAS S/Bs U- Structural constituent of cuticle Cut
CG32055 CG32055 Df/UAS S SS- Insulin-like growth factor bind CS
CG32261 Gr64a UAS S U- Taste receptor activity CS
CG33197 mbl Df/UAS Bs U- DNA binding D
CG33302 Cpr31A 24/48 S/Bs U- Structural constituent of cuticle Cut
CG42614 scrib UAS S-P U- Protein binding CS
CG4322 moody UAS S-P U- Melatonin receptor activity CS
CG4379 Pka-C1 UAS S-P U- Protein binding CS
CG4570 CG4570 24/48 S U- Transposase, Tc1-like D
CG5249 Blimp-1 UAS S-P U- Nucleic acid binding D
CG7160 Cpr78E 24/48 S U- Cuticle Cut
CG7577 ppk20 Df/UAS S U- Sodium channel activity Tra
CG7734 shn UAS S-P U- DNA binding transcription factor D
CG8084 ana UAS S-P SS- Growth factor activity CS
CG8675 CG8675 Df S-P U- -------------- CG
CG8768 CG8768 24/48 S U- NAD epimerase/dehydratase M
CG8780 tey UAS S/Bs U- Regulation of transcription D
CG9333 Oseg5 24/48 S/V+ U- WD40-repeat CGh
CG9355 dy UAS S-P U- Structural constituent of cuticle Cut

“Array” indicates the experiment which the genes were selected, experiment 1 (24/48) or experiment 2 (Df//UAS). “Ph” indicates the phenotype of nub-Gal4/UAS-RNA-i and sal EPv -Gal4/UAS-RNA-i separated by double dash: + (WT); S (wing size); P (vein pattern); S-P (wing size and vein pattern); V+ and V- (extra-veins and loss of veins); Bs (dorso-ventral wing surface adhesion); EPL (early pupal lethal). “IS” indicates the mRNA expression patterns in wild type and salm-i/salr-i discs (N: expression not detected; U: generalised expression and P: patterned expression). We indicated by “+” or “-”that the expression appears ectopic or is reduced in salmi/salri discs, respectively. “Molecular” indicates the molecular nature and simplified molecular class (MC), respectively: D (genes related with the biology of DNA), P (genes related with proteins metabolism), CG (genes without known functional domains or orthology), CS (genes encoding components of signalling pathways), CGh (genes with a known functional domain but not clear orthology relationships), M (genes encoding proteins related to the metabolism of lipids or glucids), CA (genes related with cell adhesion or the cytoskeleton), Cut (genes encoding proteins related with structural constituent of cuticle), Tra (genes related with the transport of metabolites across cellular membranes), RedOx (genes encoding proteins related with oxidation-reduction process), CD (genes related with cell death) and CR (non protein coding gene).