Table 4. PON1 genotypic distribution and odds ratios of the genotype and alleles of the Q192R polymorphism in the healthy subjects and the ACS patients.
| Genotype | Healthy subjects | ACS patients | Odds ratio | P value |
|---|---|---|---|---|
| (95% CI) | ||||
| QQ (n = 169) 55.4% | 57% (n = 56) | 55.12% (n = 113) | Reference | |
| QR (n = 106) 34.09% | 39% (n = 39) | 32.68% (n = 67) | 0.867 (0.522–1.439) | n.s.* |
| 1.05 (0.597–1842) | n.s. | |||
| RR (n = 30) 9.83% | 5% (n = 5) | 12.19% (n = 25) | 3.153 (1.04–9.49) | <0.041 |
| 4.33 (1.27–17.7) | 0.019 | |||
| Allele | ||||
| Q | 75.50% (n = 151) | 71.46% (n = 293) | Reference | |
| R | 24.50% (n = 49) | 28.53% (n = 117) | 1.3 (0.879–1.922) | <0.19 |
*n.s., not significant
Contribution of the PON1 Q192R polymorphism to ACS was estimated by logistic regression for unmatched data to obtain odds ratios for the PON1 Q192R polymorphisms. Italics bold indicate the odds ratios adjusted for age, sex, BMI and HDL cholesterol.