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The serum pro-inflammatory and anti-inflammatory cytokine levels of mice treated with PBS and CII-BPI-2 on day 31. Mice treated with three injections of CII-BPI-2 have significantly lower levels of pro-inflammatory cytokines (e.g., IFN-γ, IL-17, and TNF-α) in serum than those injected with PBS (*, p<0.01 and ‡, p<0.001). Furthermore, serum IL-10 levels were significantly higher (p<0.001) in CII-BPI-2 groups compared to the control group.
