Table 1.

Genome wide association studies and meta-analyses in multiple sclerosis.

Study	Number of Cases	Number of Controls	Tested polymorphisms	Significant non-MHC loci (novel)
IMSGC (2007) [42]	931	1862	334923	2
WTCCC1 (2007) [84]	975	1466	12374	0
Comabella (2008) [85]	242	242	528867	0
Aulchenko (2008) [86]	45	195	250000	1*
Baranzini (2009) [87]	978	883	551642	0
De Jager¶ (2009) [88]	860	1720	709690	3*
ANZgene (2009) [89]	1618	3413	302098	2
Sanna (2010) [90]	882	872	555335	1*
Nischwitz (2010) [91]	590	825	300000	3
Jakkula (2010) [92]	68	136	297343	1*
IMSGC and WTCCC2 (2011) [33]	9772	17376	475806	29*
Patsopoulos¶ (2011) [93]	1453	2176	906600	3*
Matesanz¶ (2012) [94]	296	801	130903	0
Martinelli-Boneschi (2012) [95]	197	234	277866	0

Case and control numbers refer to discovery datasets.

^*Studies that applied the conventional genome-wide significant threshold (P< 5×10−8); for the others, an arbitrary threshold (P≤10−7) was used to identify the significant loci.

^¶Studies based on meta-analysis.