Table 5. Series (grade 3 and 4) and common Nonhematologic toxicities.
| Nonhematologic Events | Grade 3, no. (%) | Grade 4, no. (%) | All Grades, no. (%) |
|---|---|---|---|
| Musculoskeletal pain | 3 (7.1) | 0 (0) | 19 (45.2) |
| Nausea and vomiting | 1 (2.4) | 0 (0) | 17 (40.5) |
| Fatigue | 0 (0) | 0 (0) | 14 (33.3) |
| Cough | 1 (2.4) | 0 (0) | 10 (23.8) |
| Headache | 0 (0) | 0 (0) | 9 (21.4) |
| Infection | 0 (0) | 0 (0) | 7 (16.7) |
| Shortness of breath | 2 (4.8) | 0 (0) | 7 (16.7) |
| Diarrhea | 1 (2.4) | 0 (0) | 6 (14.3) |
| Pain, other | 1 (2.4) | 1 (2.4) | 6 (14.3) |
| Mucositis | 0 (0) | 0 (0) | 4 (9.5) |
| Abdominal pain | 1 (2.4) | 0 (0) | 4 (9.5) |
| Loss of appetite | 0 (0) | 0 (0) | 3 (7.1) |
| Malaise | 0 (0) | 0 (0) | 3 (7.1) |
| Fever, non-neutropenic | 0 (0) | 0 (0) | 3 (7.1) |
| Congestion | 0 (0) | 0 (0) | 3 (7.1) |
| Vision loss | 1 (2.4) | 0 (0) | 1 (2.4) |
| Bowel obstruction | 1 (2.4) | 0 (0) | 1 (2.4) |
| Deep venous thrombosis | 1 (2.4) | 0 (0) | 1 (2.4) |
| Pseudogout | 1 (2.4) | 0 (0) | 1 (2.4) |
| Superior vena cava thrombosis | 1 (2.4) | 0 (0) | 1 (2.4) |
| Increased creatinine concentration | 1 (2.4) | 0 (0) | 1 (2.4) |
| Pulmonary embolism | 0 (0) | 1 (2.4) | 1 (2.4) |
a
All grade 3 and 4 adverse events are included; all-grade events that occurred in > 5% of cases are included in the table.