TABLE 1.

Estimated total costs and cure rates per treatment course of HCV treatment guidelines

Treatment regimen		Clinical recommendationa	Total estimated costb	Estimated cure ratec
SOF + IFN + RBV			$93,400	85–90 %
	12 weeks	GT3; GT4
SMV + IFN + RBV				93 %
	12 weeks	GT 4	$75,800
SOF + RBV				85–95 %
	12 weeks	GT2 non-cirrhotic	$84,200
	16 weeks	GT2 cirrhotic	$112,000
	24 weeks	GT3, GT4	$168,300
SOF + SMV				92 %
	12 weeks	GT1 non-cirrhotic; GT4	$150,400
	24 weeks	GT1 cirrhotic	$300,700
SOF + LDV				95–99 %
	8 weeks	GT1 non-cirrhotic	$63,000
	12 weeks	GT1 treatment naïve cirrhotic, treatment experienced non-cirrhotic; GT4	$94,500
	24 weeks	GT1 treatment experienced cirrhotic	$189,000
OBV/PTV/r + DSV + RBV				95–98 %
	12 weeks	GT1 treatment naïve; GT1 treatment experienced non-cirrhotic; GT1b; GT4	$83,500
	24 weeks	GT1a cirrhotic	$167,000
OBV/PTV/r + DSV	12 weeks	GT1b non-cirrhotic	$83,300	90–99 %

^aClinical recommendations based on January 2015 update of AASLD/IDSA/IAS guidelines for initiation and retreatment of hepatitis C

^bTotal estimated costs calculated based on full treatment course of individual regimens and unit costs, which were provided by RIDOC

^cEstimated cure rates and ranges obtained from clinical trials data