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Irradiated pneumococcal vaccine induced antibody titers. Irradiated or formalin-treated vaccines were administered intranasally to CD-1 mice (n = 5) with phosphate buffered saline (PBS), cholera toxin (CT), or lipid A at days 0 and 14. Pneumococcal specific immunoglobulin A in bronchoalveolar lavage fluid (BALF) (A) and total immunoglobulin (B) were measured at 5 days after final immunization.
