Table 3. Standardized incidence rate (SIR) for prostate cancer in a cohort of shift and daytime workers in a large German chemical company.
| Prostate cancer, stage T | Daytime workers | Shift workers | ||||||
|---|---|---|---|---|---|---|---|---|
| Observed cases | Expected cases | SIR | 95% CI | Observed cases | Expected cases | SIR | 95% CI | |
| Total | 191 | 126.7 | 1.51 | 1.30–1.74 | 146 | 101.3 | 1.44 | 1.22–1.70 |
| 1a | 7 | 14.9 | 0.47 | 0.19–0.97 | 10 | 12.2 | 0.82 | 0.39–1.51 |
| 2 | 126 | 61.6 | 2.05 | 1.71–2.44 | 84 | 48.6 | 1.73 | 1.38–2.14 |
| 3 | 39 | 24.5 | 1.59 | 1.13–2.18 | 32 | 19.5 | 1.64 | 1.12–2.31 |
| 4 | 5 | 3.3 | 1.50 | 0.49–3.50 | 3 | 2.7 | 1.11 | 0.22–3.25 |
| x | 14 | 22.4 | 0.63 | 0.34–1.05 | 17 | 18.2 | 0.93 | 0.54–1.49 |
| Sensitivity analysis based on 20-year latency period | ||||||||
| Total | 189 | 121.4 | 1.56 | 1.34–1.80 | 133 | 92.2 | 1.44 | 1.21–1.71 |
| 1 | 7 | 14.3 | 0.49 | 0.20–1.01 | 10 | 11.3 | 0.89 | 0.43–1.63 |
| 2 | 125 | 58.8 | 2.12 | 1.77–2.53 | 73 | 43.9 | 1.66 | 1.30–2.09 |
| 3 | 38 | 23.4 | 1.62 | 1.15–2.23 | 31 | 17.7 | 1.75 | 1.19–2.49 |
| 4 | 5 | 3.2 | 1.57 | 0.51–3.67 | 3 | 2.4 | 1.25 | 0.25–3.65 |
| x | 14 | 21.6 | 0.65 | 0.35–1.09 | 16 | 16.9 | 0.95 | 0.54–1.54 |
95% CI: 95% confidence interval; SIR: Standardized incidence rate