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. 2015 Aug 5;35(31):11125–11132. doi: 10.1523/JNEUROSCI.4615-14.2015

Figure 4.

Figure 4.

Rescue of social interaction deficits and repetitive behavior by mGluR1 and mGluR5 antagonists in Eif4ebp2−/− mice. A, Wild-type or Eif4ebp2−/− mice were tested after treatment with vehicle, JNJ16259285, or fenobam (0.5 and 24 h after). JNJ16259285 had a short-term effect, rescuing the social approach (time spent in chamber with a stranger mouse) in Eif4ebp2−/− mice at 0.5 h after treatment, but not 24 h later. Fenobam also rescued the social preference in Eif4ebp2−/− mutant mice, but 24 h after treatment. B, The effect on social preference was corroborated by the time spent by the mice sniffing the enclosure with the stranger mouse. JNJ16259285 and fenobam did not affect social preference in wild-type mice. Eif4ebp2+/+, n = 21, of which 10 were treated with JNJ16259285 and 10 with fenobam; Eif4ebp2−/−, n = 22, of which 11 were treated with JNJ16259285 and 11 with fenobam. C, In the marble-burying task, the elevated number of marbles buried by the Eif4ebp2−/− mice was reduced to control levels by JNJ16259285 and fenobam treatment. The antagonists did not affect marble burying in wild-type mice. Eif4ebp2+/+ plus vehicle, n = 12; Eif4ebp2+/+ plus JNJ16259285, n = 7; Eif4ebp2+/+ plus fenobam, n = 10; Eif4ebp2−/− plus vehicle, n = 16; Eif4ebp2−/− plus JNJ16259285, n = 9; and Eif4ebp2−/− plus fenobam, n = 13. N.S., Not significant. *p < 0.05, **p < 0.01, and ***p < 0.001.