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MOR BPND in the fasted state is greater in lean-BL compared with obese-BL (A). Dietary-induced weight loss increased MOR BPND in the fasted state in obese-PWL (B) and had modest normalizing effects on the difference between lean-BL and obese-PWL (C). Images show areas of significant binding for comparisons using voxel-by-voxel whole-brain analysis with a threshold for significance set at P = .02 for display purposes. Color bars relate to t scores. BSL, baseline.
