Table 2.
Microglial cell density in the cortex and hippocampal area of embryos derived from the control group and the group that was subjected to maternal inflammation at E11.5 or at E11.5 and E15.5.
| Brain structure | Cortex | Hippocampus | ||
|---|---|---|---|---|
| Embryonic age | E11.5 | E12.5 | E17.5 | E17.5 |
| Single injection at E11.5 | ||||
| Saline | 48.6 ± 8.8 | 34.9 ± 2.8 | 59.6 ± 5.8 | 122.5 ± 4.9 |
| Poly (I:C) | 32.2 ± 5.7 | 37.8 ± 2.9 | 56.5 ± 4.3 | 111.6 ± 5.7 |
| P value | 0.191 | 0.375 | 0.573 | 0.435 |
| Brain structure | Cortex | Hippocampus | ||
| Embryonic age | E17.5 | E17.5 | ||
| Double injection at E11.5 and E15.5 | ||||
| Saline | 59.8 ± 3.1 | 95.3 ± 4.8 | ||
| Poly (I:C) | 57.8 ± 2.2 | 91.0 ± 5.7 | ||
| P value | 0.931 | 0.699 | ||
Values are mean ± SEM of the number of microglial cells per mm2, Mann–Whitney test was used for statistical analysis. When injected at E11.5 the numbers of embryonic brains in the saline and poly (I:C) group were, respectively: E11.5 = 4/5; E12.5 = 12/7; E17.5 cortex = 6/8; E17.5 hippocampus = 5/8. When injected at E11.5 and E15.5 numbers of embryonic brains in the saline and poly (I:C) group were, respectively: E17.5 cortex = 5/6; E17.5 hippocampus = 6/6.