Table 1.

Affinity constants (pKi) for different binding compounds to Human 5-HT_2C and 5-HT_2B receptors.

Compounds	5-HT2B Human		5-HT2C Human
	pkI	Ki (nM)	pKi	Ki (nM)
Fluoxetineb	< 5	>10,000	6.95	112
Norfluoxetineb	< 5	>10,000	7.04	91
Paroxetineb	< 5	>10,000	< 5	>10,000
Fluoxetinek	< 5	>10,000	6.40±0.03	400
BW723C86k	7.33±0.03	47	7.11±0.21	78

Pharmacological determinations were performed on transfected cells expressing the relevant receptor by heterologous competition. Values are from Bonhaus et al. (1997) (^b) and Knight et al. (2004) (^k).