Figure 7.

Schematic representation of the regulation of CD24 by Ras/Raf and Ras/PI3K pathways. Rectangles represent proteins and ovals represent lipids and second messengers. Protein activation is indicated by solid arrows and inhibition indicated by solid lines with blunt ends. Potential mechanisms for cross-talk are shown in gray. The effect of U0126 and LY294002 on MEK and PI3K and on CD24 transcription is indicated by dashed lines and dash dot dash lines, respectively. The effect of sorafenib on Raf and on CD24 surface protein expression is indicated by dotted lines. The CD24 promoter is indicated with a solid line flanked by genomic DNA depicted with a dotted line. The transcription start site is indicated by a bent arrow. Abbreviations not in the main text: PLC-γ, phospholipase C- γ; PIP₃, phosphotidylinositol-3,4,5-trisphosphate; DAG, diacylglycerol; Cdc42, cell division cycle 42.