Table 3.
Expression mean and range, correlation with behavioral phenotype, and the presence of cis-regulation for the top 4 candidate genes in the amygdala, hypothalamus, pituitary, hippocampus, VTA, and adrenal gland
| Fam135a | Col19a1 | Phf3 | Ptp4a1 | |
|---|---|---|---|---|
| Amygdala | ||||
| Expression | 9.151 | 7.461 | 10.322 | 9.335 |
| (Range) | (8.88–9.35) | (7.26–7.65) | (10.12–10.48) | (8.912–9.78) |
| Phen correlate1 | NS1 | 0.0510 | NS1 | 0.0005 |
| eQTL location | none2 | Chr5: 43.571 | none2 | cis-eQTL |
| (LRS)2 | (18.9) | (26.7) | ||
| Hypothalamus | ||||
| Expression | 9.111 | 6.872 | 10.225 | 9.111 |
| (Range) | (8.73–9.38) | (6.69–7.07) | (9.83–10.37) | (8.134–9.73) |
| Phen correlate1 | NS1 | NS1 | NS1 | 0.0005 |
| eQTL location | none2 | none2 | none2 | Chr19: 4.609 |
| (LRS) | (17.5) | |||
| Pituitary Gland | ||||
| Expression | 9.431 | 6.957 | 10.806 | 9.436 |
| (Range) | (9.15–9.67) | (6.73–7.21) | (10.64–10.97) | (8.98–10.09) |
| Phen correlate1 | 0.0453 | NS1 | NS1 | NS1 |
| eQTL location | cis-eQTL | cis-eQTL | none2 | none2 |
| (LRS)2 | (20.3) | (23.8) | ||
| Hippocampus | ||||
| Expression | 9.639 | 9.302 | 11.184 | 10.700 |
| (Range) | (8.71–10.31) | (8.33–10.00) | (10.94–11.46) | (9.95–11.22) |
| Phen correlate1 | NS1 | 0.0351 | 0.0461 | 0.0104 |
| eQTL location | none2 | Chr1: 176: 535 | cis-eQTL | cis-eQTL |
| (LRS) 2 | (18.4) | (14.4) | (74.6) | |
| VTA | ||||
| Expression | 10.007 | 8.120 | 8.220 | 11.073 |
| (Range) | (9.61–10.23) | (7.62–8.99) | (7.58–8.72) | (10.75–11.29) |
| Phen correlate1 | NS1 | 0.0013 | 0.0741 | 0.0015 |
| eQTL location | none2 | none2 | none2 | cis-eQTL |
| (LRS) 2 | (37.4) | |||
| Adrenal Gland | ||||
| Expression | 9.164 | 7.029 | 10.663 | 10.277 |
| (Range) | (8.778–9.56) | (6.71–7.30) | (10.50–11.07) | (9.55–11.38) |
| Phen correlate1 | NS1 | NS1 | NS1 | 0.0317 |
| eQTL location | none2 | none2 | none2 | Chr2: 55.266 |
| (LRS) 2 | (14.1) | |||
Expression mean (“Expression”) and range (“Range”), correlation with behavioral phenotype (“Phen correlate”) and the presence of cis-regulation (“cis present”) for the top 4 candidate genes in the amygdala, hypothalamus, pituitary, hippocampus, ventral tegmental area (VTA), and adrenal gland. The phenotype examined was 12390, which is ACQ during the last 5 min (5–10 min). For the phenotype correlations the P value is shown. 1Shown are all significant P values (< 0.05) as well as those that have a trend toward significance (0.05- 0.1). All correlations that did not reach significance are denoted with NS. 2For the expression quantitative trait locus (eQTL) analyses we list eQTL LRSs that are 14 or above; eQTL LRSs that are <14 are denoted by none. Trans-eQTLs list the location, while the cis-eQTLs is located within 5 Mb of the gene itself.