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Schema of conditional, smooth muscle (SM)-specific excision of superoxide dismutase (Sod) 2 exon 3. The circled CreERT2 indicates the CreERT2 protein, expressed exclusively in SM cells. The lines at the bottom show the Sod2 gene locus. Exons 2–4, loxP sequences, and the neomycin resistance gene are indicated by the numbered black boxes, gray triangles, and boxed Neo, respectively. Floxed exon 3 is excised upon 4-hydroxytamoxifen (OHT) activation of CreERT2 in SM cells.
