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Oral AdipoRon administration significantly enhanced left ventricular (LV) ejection fraction (EF%) determined by echocardiography in WT, APN−/−, and AMPK-DN mice. Note attenuated response to AdipoRon treatment in AMPK-DN mice vs. WT mice. However, a significant portion of cardioprotection is retained in AMPK-DN mice; n = 14–16 animals/group. *P < 0.05, **P < 0.01 vs. MI/R + vehicle.
