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A: AdipoRon activated AMPK signaling (determined by ACC phosphorylation) in WT but not in AMPK-DN animals. AdipoRon significantly inhibited ischemia/reperfusion-induced superoxide production, determined by DHE staining (B), lucigenin-enhanced luminescence assay (C), and gp91phox overexpression (D) in AMPK-DN mice; n = 6–8 animals/group for DHE staining and Western analysis; n = 9–11 animals/group for lucigenin-enhanced luminescence assay. *P < 0.05, **P < 0.01 vs. MI/R + vehicle.
