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. 2015 Jun 16;309(3):E302–E310. doi: 10.1152/ajpendo.00603.2014

Fig. 4.

Fig. 4.

PRR siRNA disrupted high-glucose-induced phosphoinositide (PI3K)/Akt/mammalian target of rapamycin (mTOR)/UNC-51-like kinase-1 (ULK1) signaling pathway in podocytes. A: Western blot analysis of effect of PRR siRNA on p-PI3K p85α (Tyr508) and total PI3K protein level in response to normal or high glucose for 48 h (n = 4 in each group). B: Western blot analysis of PRR siRNA on p-Akt (Ser473) and total Akt protein level in response to normal or high glucose for 48 h (n = 4 in each group). C: Western blot analysis of PRR siRNA on p-mTOR (Ser2448) and total mTOR protein level in response to treatment with normal or high glucose for 48 h (n = 5 in each group). D: Western blot analysis of PRR siRNA on p-ULK1 (Ser757) and total ULK1 protein level in response to treatment with normal or high glucose for 48 h (n = 4 in each group). Black bars, Scr siRNA; gray bars, PRR siRNA. Data are presented as means ± SE. *P < 0.05 vs. NG; #P < 0.05 vs. HG + Scr siRNA.