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. 2015 Jul 22;6:7830. doi: 10.1038/ncomms8830

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Cartoon of CLASH-DHFR/HCA for control of HCA with DHFR: DHFR acts as an effector by binding to the tethered trimethoprim (T) and leading to the unbinding of benzenesulfonamide (SA) from HCA. (b) Chemical structure of the labelling molecule. (c) The opening of the biosensor can be detected by the increase in emission ratio on addition of DHFR. (d) Titrations with the anticancer agent methotrexate (MTX) at three different free DHFR concentrations show that the colour of the luminescence emission changes at the threshold concentration. Picture taken with a Canon 600D camera. The colour balance was modified to give a clear difference between the blue and red colours.