Table 4.
NMR data of compound 4 and NNEI indazole analog
| No. | NNEI 1H-indazole analoga | Compound 4 b | |
|---|---|---|---|
| 13C | 13C | 1H | |
| 1 | 160.9 | 159.0 | – |
| 2′ | – | – | |
| 3′ | 137.3 | 127.1 | – |
| 3′a | 123.0 | 120.6 | – |
| 4′ | 122.9 | 118.2 | 7.94, 1H, d, J = 9.6 Hz, overlapped |
| 5′ | 122.9 | 124.9 | 7.34, 1H, td, J = 7.6, 0.7 Hz |
| 6′ | 126.9 | 126.3 | 7.40, 1H, ddd, J = 7.6, 6.5, 1.0 Hz |
| 7′ | 109.4 | 119.0 | 7.88, 1H, d, J = 8.9 Hz |
| 7′a | 141.1 | 147.3 | – |
| 1″ | 49.6 | 53.4 | 4.89, 2H, t, J = 7.2 Hz |
| 2″ | 29.5 | 31.0 | 2.04, 2H, m |
| 3″ | 29.0 | 28.9 | 1.35, 2H, m, overlapped |
| 4″ | 22.3 | 22.3 | 1.35, 2H, m, overlapped |
| 5″ | 14.0 | 14.0 | 0.87, 3H, t, J = 7.2 Hz |
| 1″′ | 132.4 | 131.8 | – |
| 2″′ | 119.4 | 121.1 | 8.08, 1H, d, J = 7.6 Hz |
| 3″′ | 126.0 | 126.2 | 7.55, 1H, m, overlapped |
| 4″′ | 125.0 | 126.6 | 7.79, 1H, d, J = 8.3 Hz |
| 4″′a | 134.2 | 134.3 | – |
| 5″′ | 128.8 | 129.0 | 7.93, 1H, m, overlapped |
| 6″′ | 125.9 | 126.8 | 7.54, 1H, m, overlapped |
| 7″′ | 126.2 | 125.8 | 7.57, 1H, m, overlapped |
| 8″′ | 120.5 | 120.4 | 7.92, 1H, m, overlapped |
| 8″′a | 126.7 | 127.2 | – |
| NH | – | – | 8.25, 1H, brs |
aRecorded in CDCl3 at 800 MHz (1H) and 200 MHz (13C), respectively; data in δ ppm (J in Hz)
bRecorded in CDCl3 at 600 MHz (1H) and 150 MHz (13C), respectively; data in δ ppm (J in Hz)