Table 2. IC50 Values of Various Formulations of Tvlocrebrine in A431 and A549 Cells.
| A431 cells | IC50 at physiological pH (nM) | IC50 at acidic pH (nM) |
|---|---|---|
| free drug | 210 | 432 |
| nontargeted nanoparticles | 154 | 132 |
| targeted nanoparticles | 31 | 28 |
| A549 cells | IC50 at physiological pH (nM) | IC50 at acidic pH (nM) |
|---|---|---|
| free drug | 37 | 361 |
| nontargeted nanoparticles | 28 | 47 |
| targeted nanoparticles | 7 | 24 |