TABLE 1.

Upregulated proteins in RESTless tumors as determined by RPPA analysis

Gene symbol	Protein	RPPA antibody	Fold changea
IRS1	Insulin receptor substrate 1	IRS1	2.21**
IGFBP2	Insulin-like growth factor binding protein 2	IGFBP2	2.01**
EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1	4EBP1	1.91**
CLDN7	Claudin 7	Claudin 7	1.85*
CCND1	Cyclin D1	Cyclin D1	1.84**
TAZ	Tafazzin	pTAZS89	1.75*
MSH2	MutS protein homolog 2	MSH2	1.68*
EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1	p4EBP1T70	1.66*
RB1	Retinoblastoma	pRbS807/S811	1.65*
BRAF	Rapidly accelerated fibrosarcoma	B-Raf	1.63*
XRCC1	X-ray repair cross-complementing protein 1	XRCC1	1.62*
RPS6KB1	Ribosomal protein S6 kinase, 70 kDa, polypeptide 1	p70S6K	1.61*
IGF1R	Insulin-like growth factor 1 receptor	IGF1Rbeta	1.57*
MAPK9	Mitogen-activated protein kinase 9	JNK2	1.48*
EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1	p4EBP1T37	1.45*

^a*, P value of <0.05; **, P value of <0.005.