FIG 8.

Pathway and correlation studies of target genes of WT and mutant SRSF2. (A) Top biological functions of the 470 common and same-direction targets of Δ8aa and P95H based on IPA. The −log(P value) (x axis) corresponds to the significance of the functions with respect to the data set. GNRH, gonadotropin-releasing hormone. (B) Venn diagram showing significant overlapped events among 470 common targets of P95H and Δ8aa cells versus WT SRSF2 cells relative to cells expressing only shRNA. Events that changed in the same direction or in opposite directions are also listed separately.