FIG 3.

Inhibition of p300 affects several signaling pathways in the liver. (A) List of pathways with altered gene expression determined by RNA-Seq analysis of livers of three WT and three dnp300 mice. (B) Differentially expressed genes that code for phosphoproteins. The names of these genes are shown in Table S2 in the supplemental material. Bar graphs show verification of the expression of genes selected from this category by QRT-PCR. (C) List of differentially expressed genes involved in chromatin remodeling. Bar graphs show verification of the expression of genes selected from this category by QRT-PCR. (D) List of oncogenes differentially expressed in dnp300 versus WT mice. Bar graphs show verification of the expression of genes selected from this category by QRT-PCR. (E) List of differentially expressed genes clustered in the apoptosis pathway. Bar graphs show verification of the expression of genes selected from this category by QRT-PCR. For all bar graphs, data represent means ± SD (n = 3). *, P < 0.05.